Astrocyte-to-neuron intercellular prion transfer is mediated by cell-cell contact

Prion diseases are caused by misfolding of the cellular protein PrP(C) to an infectious conformer, PrP(Sc). Intercellular PrP(Sc) transfer propagates conversion and allows infectivity to move from the periphery to the brain. However, how prions spread between cells of the central nervous system is u...

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Detalles Bibliográficos
Autores principales: Victoria, Guiliana Soraya, Arkhipenko, Alexander, Zhu, Seng, Syan, Sylvie, Zurzolo, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746738/
https://www.ncbi.nlm.nih.gov/pubmed/26857744
http://dx.doi.org/10.1038/srep20762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746738/
https://www.ncbi.nlm.nih.gov/pubmed/26857744
http://dx.doi.org/10.1038/srep20762

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