AMP-activated protein kinase contributes to zinc-induced neuronal death via activation by LKB1 and induction of Bim in mouse cortical cultures

BACKGROUND: We reported that zinc neurotoxicity, a key mechanism of ischemic neuronal death, was mediated by poly ADP-ribose polymerase (PARP) over-activation following NAD(+)/ATP depletion in cortical cultures. Because AMP-activated protein kinase (AMPK) can be activated by ATP depletion, and AMPK...

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Detalles Bibliográficos
Autores principales: Eom, Jae-Won, Lee, Jong-Min, Koh, Jae-Young, Kim, Yang-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746814/
https://www.ncbi.nlm.nih.gov/pubmed/26856538
http://dx.doi.org/10.1186/s13041-016-0194-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746814/
https://www.ncbi.nlm.nih.gov/pubmed/26856538
http://dx.doi.org/10.1186/s13041-016-0194-6

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