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Soluble adenylyl cyclase mediates hydrogen peroxide-induced changes in epithelial barrier function

BACKGROUND: Elevated H(2)O(2) levels are associated with inflammatory diseases and H(2)O(2) exposure is known to disrupt epithelial barrier function, leading to increased permeability and decreased electrical resistance. In normal human bronchial epithelial (NHBE) cells, fully differentiated at the...

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Detalles Bibliográficos
Autores principales: Ivonnet, Pedro, Unwalla, Hoshang, Salathe, Matthias, Conner, Gregory E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746823/
https://www.ncbi.nlm.nih.gov/pubmed/26857816
http://dx.doi.org/10.1186/s12931-016-0329-4