Cargando…

Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways

BACKGROUND: Paris polyphylla is an oriental folk medicine that has anticancer activities both in vivo and in vitro. Polyphyllin VII (PP7), a pennogenyl saponin from P. polyphylla has been found to exert strong anticancer activity. However, the underlying mechanisms are poorly understood. In the pres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Chao, Jia, Xuejing, Bao, Jiaolin, Chen, Shenghui, Wang, Kai, Zhang, Yulin, Li, Peng, Wan, Jian-Bo, Su, Huanxing, Wang, Yitao, Mei, Zhinan, He, Chengwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746894/ https://www.ncbi.nlm.nih.gov/pubmed/26861252 http://dx.doi.org/10.1186/s12906-016-1036-x

Ejemplares similares

Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells
por: Zhang, Chao, et al.
Publicado: (2016)

In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways
por: Zhang, Chao, et al.
Publicado: (2019)

Low Doses of Camptothecin Induced Hormetic and Neuroprotective Effects in PC12 Cells
por: Zhang, Chao, et al.
Publicado: (2015)

Anti-angiogenesis and anti-metastasis effects of Polyphyllin VII on Hepatocellular carcinoma cells in vitro and in vivo
por: Zhang, Chao, et al.
Publicado: (2021)

Hormetic Effect of Berberine Attenuates the Anticancer Activity of Chemotherapeutic Agents
por: Bao, Jiaolin, et al.
Publicado: (2015)

Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide
por: Pang, Dejiang, et al.
Publicado: (2019)

A new agent developed by biotransformation of polyphyllin VII inhibits chemoresistance in breast cancer
por: He, Dong-Xu, et al.
Publicado: (2015)

Anti-melanoma activity of Forsythiae Fructus aqueous extract in mice involves regulation of glycerophospholipid metabolisms by UPLC/Q-TOF MS-based metabolomics study
por: Bao, Jiaolin, et al.
Publicado: (2016)

Polyphyllin VII attenuated RANKL-induced osteoclast differentiation via inhibiting of TRAF6/c-Src/PI3K pathway and ROS production
por: Zhou, Long, et al.
Publicado: (2020)

Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer
por: Song, Cheng, et al.
Publicado: (2021)

Role of the Death Receptor and Endoplasmic Reticulum Stress Signaling Pathways in Polyphyllin I-Regulated Apoptosis of Human Hepatocellular Carcinoma HepG2 Cells
por: Luo, Qihui, et al.
Publicado: (2018)

Polyphyllin VII induces CTC anoikis to inhibit lung cancer metastasis through EGFR pathway regulation
por: Que, Zujun, et al.
Publicado: (2023)

Mitochondrial ROS contribute to oridonin-induced HepG2 apoptosis through PARP activation
por: Liu, Xiaoning, et al.
Publicado: (2018)

Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis
por: Ahmad, Bashir, et al.
Publicado: (2021)

Nevirapine induced mitochondrial dysfunction in HepG2 cells
por: Paemanee, Atchara, et al.
Publicado: (2017)

Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death
por: Wang, Kai, et al.
Publicado: (2016)

Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer
por: Zhao, Liubiqi, et al.
Publicado: (2021)

Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation
por: Yuan, Yong-Liang, et al.
Publicado: (2019)

2,4,6-Trinitrotoluene Induces Apoptosis via ROS-Regulated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in HepG2 and Hep3B Cells
por: Liao, Hung-Yu, et al.
Publicado: (2017)

Ultrasound-Assisted Extraction, Antioxidant and Anticancer Activities of the Polysaccharides from Rhynchosia minima Root
por: Jia, Xuejing, et al.
Publicado: (2015)

MCU-knockdown attenuates high glucose-induced inflammation through regulating MAPKs/NF-κB pathways and ROS production in HepG2 cells
por: Panahi, Ghodratollah, et al.
Publicado: (2018)

Surfactin-Induced Apoptosis Through ROS–ERS–Ca(2+)-ERK Pathways in HepG2 Cells
por: Wang, Chun-ling, et al.
Publicado: (2013)

Zerumbone suppresses the potential of growth and metastasis in hepatoma HepG2 cells via the MAPK signaling pathway
por: Lv, Tao, et al.
Publicado: (2018)

Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways
por: Zhang, Chao, et al.
Publicado: (2016)

Sodium Butyrate-Modulated Mitochondrial Function in High-Insulin Induced HepG2 Cell Dysfunction
por: Zhao, Tingting, et al.
Publicado: (2020)

Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways
por: Zhang, Chao, et al.
Publicado: (2017)

Sublethal hyperthermia enhances anticancer activity of doxorubicin in chronically hypoxic HepG2 cells through ROS-dependent mechanism
por: Wang, Qi, et al.
Publicado: (2021)

Lanosterol synthase loss of function decreases the malignant phenotypes of HepG2 cells by deactivating the Src/MAPK signaling pathway
por: Sun, Xiaomei, et al.
Publicado: (2023)

Peroxiredoxin 5 protects HepG2 cells from ethyl β-carboline-3-carboxylate-induced cell death via ROS-dependent MAPK signalling pathways
por: Xie, Dan-Ping, et al.
Publicado: (2022)

Germacrone induces caspase-3/GSDME activation and enhances ROS production, causing HepG2 pyroptosis
por: Sun, Xinfeng, et al.
Publicado: (2022)

The synergistic anticancer effect of formosanin C and polyphyllin VII based on caspase‐mediated cleavage of Beclin1 inhibiting autophagy and promoting apoptosis
por: Cui, Jingxia, et al.
Publicado: (2018)

Targeting macrophage priming by polyphyllin VII triggers anti-tumor immunity via STING-governed cytotoxic T-cell infiltration in lung cancer
por: Yu, Jinglu, et al.
Publicado: (2020)

Synergistic Effects of The Enhancements to Mitochondrial ROS, p53 Activation and Apoptosis Generated by Aspartame and Potassium Sorbate in HepG2 Cells
por: Qu, Daofeng, et al.
Publicado: (2019)

Cigarette smoke extract stimulates PCSK9 production in HepG2 cells via ROS/NF-κB signaling
por: Ma, Baitao, et al.
Publicado: (2021)

Impairment of Mitochondrial Biogenesis and Dynamics Involved in Isoniazid-Induced Apoptosis of HepG2 Cells Was Alleviated by p38 MAPK Pathway
por: Zhang, Tianguang, et al.
Publicado: (2017)

Naringenin Induces HepG2 Cell Apoptosis via ROS-Mediated JAK-2/STAT-3 Signaling Pathways
por: Zhang, Ming, et al.
Publicado: (2023)

The roles of p38MAPK and caspase-3 in DADS-induced apoptosis in human HepG2 cells
por: Ji, Chunxiao, et al.
Publicado: (2010)

S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway
por: Wu, Rui, et al.
Publicado: (2023)

Polyphyllin VII induces apoptosis and autophagy via mediating H(2)O(2) levels and the JNK pathway in human osteosarcoma U2OS cells
por: Li, Xiangde, et al.
Publicado: (2021)

Curcumin and Andrographolide Co-Administration Safely Prevent Steatosis Induction and ROS Production in HepG2 Cell Line
por: Pipitone, Rosaria Maria, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_74n16dv2qe1tt10lcfpqkh795a