Indirect p53-dependent transcriptional repression of Survivin, CDC25C, and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex

The transcription factor p53 is central to cell cycle control by downregulation of cell cycle-promoting genes upon cell stress such as DNA damage. Survivin (BIRC5), CDC25C, and PLK1 encode important cell cycle regulators that are repressed following p53 activation. Here, we provide evidence that p53...

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Detalles Bibliográficos
Autores principales: Fischer, Martin, Quaas, Marianne, Nickel, Annina, Engeland, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747163/
https://www.ncbi.nlm.nih.gov/pubmed/26595675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747163/
https://www.ncbi.nlm.nih.gov/pubmed/26595675

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