Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans

Lowering insulin-IGF-1-like signalling (IIS) activates FOXO transcription factors (TF) to extend life span across species. To study the dynamics of FOXO chromatin occupancy under this condition in C. elegans, we report the first recruitment profile of endogenous DAF-16 and show that the response is...

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Detalles Bibliográficos
Autores principales: Kumar, Neeraj, Jain, Vaibhav, Singh, Anupama, Jagtap, Urmila, Verma, Sonia, Mukhopadhyay, Arnab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747164/
https://www.ncbi.nlm.nih.gov/pubmed/26539642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747164/
https://www.ncbi.nlm.nih.gov/pubmed/26539642

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