Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis

Palmitic acid (PA) induces hepatocyte apoptosis and fuels de novo ceramide synthesis in the endoplasmic reticulum (ER). Myristic acid (MA), a free fatty acid highly abundant in copra/palmist oils, is a predictor of nonalcoholic steatohepatitis (NASH) and stimulates ceramide synthesis. Here we invest...

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Detalles Bibliográficos
Autores principales: Martínez, Laura, Torres, Sandra, Baulies, Anna, Alarcón-Vila, Cristina, Elena, Montserrat, Fabriàs, Gemma, Casas, Josefina, Caballeria, Joan, Fernandez-Checa, Jose C., García-Ruiz, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper: Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747168/
https://www.ncbi.nlm.nih.gov/pubmed/26539645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747168/
https://www.ncbi.nlm.nih.gov/pubmed/26539645

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