Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells

Multiple myeloma (MM) is characterized by the production of monoclonal protein (MP). We have shown previously that disruption of the isoprenoid biosynthetic pathway (IBP) causes a block in MP secretion through a disruption of Rab GTPase activity, leading to an enhanced unfolded protein response and...

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Detalles Bibliográficos
Autores principales: Dykstra, Kaitlyn M., Allen, Cheryl, Born, Ella J., Tong, Huaxiang, Holstein, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research paper: Autophagy and Cell Death
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747172/
https://www.ncbi.nlm.nih.gov/pubmed/26595805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747172/
https://www.ncbi.nlm.nih.gov/pubmed/26595805

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