A new class of small molecule estrogen receptor-alpha antagonists that overcome anti-estrogen resistance

Previous studies indicate that BRCA1 protein binds to estrogen receptor-alpha (ER) and inhibits its activity. Here, we found that BRCA1 over-expression not only inhibits ER activity in anti-estrogen-resistant LCC9 cells but also partially restores their sensitivity to Tamoxifen. To simulate the mech...

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Detalles Bibliográficos
Autores principales: Ma, Yongxian, Preet, Anju, Tomita, York, De Oliveira, Eliseu, Zhang, Li, Ueda, Yumi, Clarke, Robert, Brown, Milton, Rosen, Eliot M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747340/
https://www.ncbi.nlm.nih.gov/pubmed/26575173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747340/
https://www.ncbi.nlm.nih.gov/pubmed/26575173

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