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Bis-cyclopropane analog of disorazole C(1) is a microtubule-destabilizing agent active in abcb1-overexpressing human colon cancer cells
The novel, chemically stabilized disorazole analog, (−)-CP(2)-disorazole C(1) (1) displayed potent anti-proliferative activity against a broad-spectrum of human colorectal cancer cells. HCT15 and H630R1 cell lines expressing high basal levels of the ABCB1 protein, known to cause multi-drug resistanc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747374/ https://www.ncbi.nlm.nih.gov/pubmed/26506423 |