Bis-cyclopropane analog of disorazole C(1) is a microtubule-destabilizing agent active in abcb1-overexpressing human colon cancer cells

The novel, chemically stabilized disorazole analog, (−)-CP(2)-disorazole C(1) (1) displayed potent anti-proliferative activity against a broad-spectrum of human colorectal cancer cells. HCT15 and H630R1 cell lines expressing high basal levels of the ABCB1 protein, known to cause multi-drug resistanc...

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Detalles Bibliográficos
Autores principales: Wu, Shaoyu, Guo, Zhijian, Hopkins, Chad D., Wei, Ning, Chu, Edward, Wipf, Peter, Schmitz, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747374/
https://www.ncbi.nlm.nih.gov/pubmed/26506423

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