Highly Accurate Structure-Based Prediction of HIV-1 Coreceptor Usage Suggests Intermolecular Interactions Driving Tropism

HIV-1 entry into host cells is mediated by interactions between the V3-loop of viral glycoprotein gp120 and chemokine receptor CCR5 or CXCR4, collectively known as HIV-1 coreceptors. Accurate genotypic prediction of coreceptor usage is of significant clinical interest and determination of the factor...

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Detalles Bibliográficos
Autores principales: Kieslich, Chris A., Tamamis, Phanourios, Guzman, Yannis A., Onel, Melis, Floudas, Christodoulos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747591/
https://www.ncbi.nlm.nih.gov/pubmed/26859389
http://dx.doi.org/10.1371/journal.pone.0148974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747591/
https://www.ncbi.nlm.nih.gov/pubmed/26859389
http://dx.doi.org/10.1371/journal.pone.0148974

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