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Highly Accurate Structure-Based Prediction of HIV-1 Coreceptor Usage Suggests Intermolecular Interactions Driving Tropism

HIV-1 entry into host cells is mediated by interactions between the V3-loop of viral glycoprotein gp120 and chemokine receptor CCR5 or CXCR4, collectively known as HIV-1 coreceptors. Accurate genotypic prediction of coreceptor usage is of significant clinical interest and determination of the factor...

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Detalles Bibliográficos
Autores principales:	Kieslich, Chris A., Tamamis, Phanourios, Guzman, Yannis A., Onel, Melis, Floudas, Christodoulos A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747591/ https://www.ncbi.nlm.nih.gov/pubmed/26859389 http://dx.doi.org/10.1371/journal.pone.0148974

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