Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks. We have previously...

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Detalles Bibliográficos
Autores principales: Zimmer, Jutta, Tacconi, Eliana M.C., Folio, Cecilia, Badie, Sophie, Porru, Manuela, Klare, Kerstin, Tumiati, Manuela, Markkanen, Enni, Halder, Swagata, Ryan, Anderson, Jackson, Stephen P., Ramadan, Kristijan, Kuznetsov, Sergey G., Biroccio, Annamaria, Sale, Julian E., Tarsounas, Madalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747901/
https://www.ncbi.nlm.nih.gov/pubmed/26748828
http://dx.doi.org/10.1016/j.molcel.2015.12.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747901/
https://www.ncbi.nlm.nih.gov/pubmed/26748828
http://dx.doi.org/10.1016/j.molcel.2015.12.004

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