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Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H(3) receptors
BACKGROUND: Histamine H(3) receptor (H(3)R) is a potential therapeutic target of sleep- and cognition-related disorders. The purpose of the present study is to develop a novel positron emission tomography (PET) ligand for H(3)Rs from dihydroquinolinone derivatives, which we previously found to have...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747952/ https://www.ncbi.nlm.nih.gov/pubmed/26860293 http://dx.doi.org/10.1186/s13550-016-0170-2 |