The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin

Anthracyclines such as daunorubicin are anticancer agents that are transported into cells, and exert cytotoxicity by blocking DNA metabolism. Although there is evidence for active uptake of anthracyclines into cells, the specific transporter involved in this process has not been identified. Using th...

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Detalles Bibliográficos
Autores principales: Andreev, Emil, Brosseau, Nicolas, Carmona, Euridice, Mes-Masson, Anne-Marie, Ramotar, Dindial
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748219/
https://www.ncbi.nlm.nih.gov/pubmed/26861753
http://dx.doi.org/10.1038/srep20508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748219/
https://www.ncbi.nlm.nih.gov/pubmed/26861753
http://dx.doi.org/10.1038/srep20508

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