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The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin
Anthracyclines such as daunorubicin are anticancer agents that are transported into cells, and exert cytotoxicity by blocking DNA metabolism. Although there is evidence for active uptake of anthracyclines into cells, the specific transporter involved in this process has not been identified. Using th...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748219/ https://www.ncbi.nlm.nih.gov/pubmed/26861753 http://dx.doi.org/10.1038/srep20508 |