Co-transfection of decorin and interleukin-10 modulates pro-fibrotic extracellular matrix gene expression in human tenocyte culture

Extracellular matrix synthesis and remodelling are driven by increased activity of transforming growth factor beta 1 (TGF-β1). In tendon tissue repair, increased activity of TGF-β1 leads to progressive fibrosis. Decorin (DCN) and interleukin 10 (IL-10) antagonise pathological collagen synthesis by e...

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Detalles Bibliográficos
Autores principales: Abbah, Sunny A., Thomas, Dilip, Browne, Shane, O’Brien, Timothy, Pandit, Abhay, Zeugolis, Dimitrios I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748261/
https://www.ncbi.nlm.nih.gov/pubmed/26860065
http://dx.doi.org/10.1038/srep20922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748261/
https://www.ncbi.nlm.nih.gov/pubmed/26860065
http://dx.doi.org/10.1038/srep20922

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