TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity

Topoisomerase IIβ-binding protein 1 (TOPBP1) participates in DNA replication and DNA damage response; however, its role in DNA repair and relevance for human cancer remain unclear. Here, through an unbiased small interfering RNA screen, we identified and validated TOPBP1 as a novel determinant whose...

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Detalles Bibliográficos
Autores principales: Moudry, Pavel, Watanabe, Kenji, Wolanin, Kamila M., Bartkova, Jirina, Wassing, Isabel E., Watanabe, Sugiko, Strauss, Robert, Troelsgaard Pedersen, Rune, Oestergaard, Vibe H., Lisby, Michael, Andújar-Sánchez, Miguel, Maya-Mendoza, Apolinar, Esashi, Fumiko, Lukas, Jiri, Bartek, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748576/
https://www.ncbi.nlm.nih.gov/pubmed/26811421
http://dx.doi.org/10.1083/jcb.201507042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748576/
https://www.ncbi.nlm.nih.gov/pubmed/26811421
http://dx.doi.org/10.1083/jcb.201507042

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