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Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6

Prokaryotic CRISPR–Cas systems provide an RNA-guided mechanism for genome defense against mobile genetic elements such as viruses and plasmids. In type III-A CRISPR–Cas systems, the RNA-guided multisubunit Csm effector complex targets both single-stranded RNAs and double-stranded DNAs. In addition t...

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Detalles Bibliográficos
Autores principales: Niewoehner, Ole, Jinek, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748810/
https://www.ncbi.nlm.nih.gov/pubmed/26763118
http://dx.doi.org/10.1261/rna.054098.115