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Cross-backbone templating; ribodinucleotides made on poly(C)

G(5′)pp(5′)G synthesis from pG and chemically activated 2MeImpG is accelerated by the addition of complementary poly(C), but affected only slightly by poly(G) and not at all by poly(U) and poly(A). This suggests that 3′–5′ poly(C) is a template for uncatalyzed synthesis of 5′–5′ GppG, as was poly(U)...

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Detalles Bibliográficos
Autores principales: Majerfeld, Irene, Puthenvedu, Deepa, Yarus, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748817/
https://www.ncbi.nlm.nih.gov/pubmed/26759450
http://dx.doi.org/10.1261/rna.054866.115