Activating the branch-forming splicing pathway by reengineering the ribozyme component of a natural group II intron

When assayed in vitro, group IIC self-splicing introns, which target bacterial Rho-independent transcription terminators, generally fail to yield branched products during splicing despite their possessing a seemingly normal branchpoint. Starting with intron O.i.I1 from Oceanobacillus iheyensis, whos...

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Detalles Bibliográficos
Autores principales: Monachello, Dario, Michel, François, Costa, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748821/
https://www.ncbi.nlm.nih.gov/pubmed/26769855
http://dx.doi.org/10.1261/rna.054643.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748821/
https://www.ncbi.nlm.nih.gov/pubmed/26769855
http://dx.doi.org/10.1261/rna.054643.115

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