A dual fluorescent reporter for the investigation of methionine mistranslation in live cells

In mammalian cells under oxidative stress, the methionyl-tRNA synthetase (MetRS) misacylates noncognate tRNAs at frequencies as high as 10% distributed among up to 28 tRNA species. Instead of being detrimental for the cell, misincorporation of methionine residues in the proteome reduces the risk of...

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Detalles Bibliográficos
Autores principales: Gomes, Ana Cristina, Kordala, Anna J., Strack, Rita, Wang, Xiaoyun, Geslain, Renaud, Delaney, Kamila, Clark, Wesley C., Keenan, Robert, Pan, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748823/
https://www.ncbi.nlm.nih.gov/pubmed/26729921
http://dx.doi.org/10.1261/rna.054163.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748823/
https://www.ncbi.nlm.nih.gov/pubmed/26729921
http://dx.doi.org/10.1261/rna.054163.115

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