Potentiation of ΔF508- and G551D-CFTR-Mediated Cl(-) Current by Novel Hydroxypyrazolines

The most common mutation of CFTR, affecting approximately 90% of CF patients, is a deletion of phenylalanine at position 508 (F508del, ΔF508). Misfolding of ΔF508-CFTR impairs both its trafficking to the plasma membrane and its chloride channel activity. To identify small molecules that can restore...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Jinhong, Khloya, Poonam, Seo, Yohan, Kumar, Satish, Lee, Ho K., Jeon, Dong-Kyu, Jo, Sungwoo, Sharma, Pawan K., Namkung, Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749168/
https://www.ncbi.nlm.nih.gov/pubmed/26863533
http://dx.doi.org/10.1371/journal.pone.0149131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749168/
https://www.ncbi.nlm.nih.gov/pubmed/26863533
http://dx.doi.org/10.1371/journal.pone.0149131

Ejemplares similares