Hydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations

p53, a tumor suppressor protein, has been proven to regulate the cell cycle, apoptosis, and DNA repair to prevent malignant transformation. MDM2 regulates activity of p53 and inhibits its binding to DNA. In the present study, we elucidated the MDM2 inhibition potential of polyphenols (Apigenin, Fise...

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Detalles Bibliográficos
Autores principales: Verma, Sharad, Grover, Sonam, Tyagi, Chetna, Goyal, Sukriti, Jamal, Salma, Singh, Aditi, Grover, Abhinav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749206/
https://www.ncbi.nlm.nih.gov/pubmed/26863418
http://dx.doi.org/10.1371/journal.pone.0149014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749206/
https://www.ncbi.nlm.nih.gov/pubmed/26863418
http://dx.doi.org/10.1371/journal.pone.0149014

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