Cargando…
Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension
Serotonergic anorexigens are the primary pharmacologic risk factor associated with pulmonary arterial hypertension (PAH), and the resulting PAH is clinically indistinguishable from the heritable form of disease, associated with BMPR2 mutations. Both BMPR2 mutation and agonists to the serotonin recep...
Autores principales: | West, James D., Carrier, Erica J., Bloodworth, Nathaniel C., Schroer, Alison K., Chen, Peter, Ryzhova, Larisa M., Gladson, Santhi, Shay, Sheila, Hutcheson, Joshua D., Merryman, W. David |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749293/ https://www.ncbi.nlm.nih.gov/pubmed/26863209 http://dx.doi.org/10.1371/journal.pone.0148657 |
Ejemplares similares
-
rhACE2 Therapy Modifies Bleomycin-Induced Pulmonary Hypertension via Rescue of Vascular Remodeling
por: Rathinasabapathy, Anandharajan, et al.
Publicado: (2018) -
Expression of a Human Caveolin-1 Mutation in Mice Drives Inflammatory and Metabolic Defect-Associated Pulmonary Arterial Hypertension
por: Rathinasabapathy, Anandharajan, et al.
Publicado: (2020) -
Adverse effects of BMPR2 suppression in macrophages in animal models of pulmonary hypertension
por: West, James, et al.
Publicado: (2020) -
Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling
por: Pickworth, Josephine, et al.
Publicado: (2017) -
Heritable forms of hypertension
por: Vehaskari, V. Matti
Publicado: (2009)