PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

In Hedgehog (Hh) signaling, binding of Hh to the Patched-Interference Hh (Ptc-Ihog) receptor complex relieves Ptc inhibition on Smoothened (Smo). A longstanding question is how Ptc inhibits Smo and how such inhibition is relieved by Hh stimulation. In this study, we found that Hh elevates production...

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Detalles Bibliográficos
Autores principales: Jiang, Kai, Liu, Yajuan, Fan, Junkai, Zhang, Jie, Li, Xiang-An, Evers, B. Mark, Zhu, Haining, Jia, Jianhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749301/
https://www.ncbi.nlm.nih.gov/pubmed/26863604
http://dx.doi.org/10.1371/journal.pbio.1002375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749301/
https://www.ncbi.nlm.nih.gov/pubmed/26863604
http://dx.doi.org/10.1371/journal.pbio.1002375

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