TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes

The induction of high levels of systemic and mucosal humoral immunity is a key goal for many prophylactic vaccines. However, adjuvant strategies developed in mice have often performed poorly in the clinic. Due to their closer similarity to humans, minipigs may provide a more accurate picture of adju...

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Detalles Bibliográficos
Autores principales: McKay, Paul F., King, Deborah F. L., Mann, Jamie F. S., Barinaga, Guillermo, Carter, Darrick, Shattock, Robin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749393/
https://www.ncbi.nlm.nih.gov/pubmed/26862758
http://dx.doi.org/10.1371/journal.pone.0148984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749393/
https://www.ncbi.nlm.nih.gov/pubmed/26862758
http://dx.doi.org/10.1371/journal.pone.0148984

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