Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis

Adrenergic stimulation adversely affects tumor growth and metastasis, but the underlying mechanisms are not well understood. Here, we uncovered a novel mechanism by which catecholamines induce inflammation by increasing prostaglandin E2 (PGE2) levels in ovarian cancer cells. Metabolic changes in tum...

Descripción completa

Detalles Bibliográficos
Autores principales: Nagaraja, Archana S., Dorniak, Piotr L., Sadaoui, Nouara C., Kang, Yu, Lin, Tan, Armaiz-Pena, Guillermo, Wu, Sherry Y., Rupaimoole, Rajesha, Allen, Julie K., Gharpure, Kshipra M., Pradeep, Sunila, Zand, Behrouz, Previs, Rebecca A., Hansen, Jean M., Ivan, Cristina, Rodriguez-Aguayo, Cristian, Yang, Peiying, Lopez-Berestein, Gabriel, Lutgendorf, Susan K., Cole, Steve W., Sood, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749473/
https://www.ncbi.nlm.nih.gov/pubmed/26257064
http://dx.doi.org/10.1038/onc.2015.302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749473/
https://www.ncbi.nlm.nih.gov/pubmed/26257064
http://dx.doi.org/10.1038/onc.2015.302

Ejemplares similares