Exploitation of the Apoptosis-Primed State of MYCN-Amplified Neuroblastoma to Develop a Potent and Specific Targeted Therapy Combination

Fewer than half of children with high-risk neuroblastoma survive. Many of these tumors harbor high-level amplification of MYCN, which correlates with poor disease outcome. Using data from our large drug screen we predicted, and subsequently demonstrated, that MYCN-amplified neuroblastomas are sensit...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ham, Jungoh, Costa, Carlotta, Sano, Renata, Lochmann, Timothy L., Sennott, Erin M., Patel, Neha U., Dastur, Anahita, Gomez-Caraballo, Maria, Krytska, Kateryna, Hata, Aaron N., Floros, Konstantinos V., Hughes, Mark T., Jakubik, Charles T., Heisey, Daniel A.R., Ferrell, Justin T., Bristol, Molly L., March, Ryan J., Yates, Craig, Hicks, Mark A., Nakajima, Wataru, Gowda, Madhu, Windle, Brad E., Dozmorov, Mikhail G., Garnett, Mathew J., McDermott, Ultan, Harada, Hisashi, Taylor, Shirley M., Morgan, Iain M., Benes, Cyril H., Engelman, Jeffrey A., Mossé, Yael P., Faber, Anthony C.
Μορφή: Online Άρθρο Κείμενο
Γλώσσα:English
Έκδοση: Cell Press 2016
Θέματα:
Article
Διαθέσιμο Online:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749542/
https://www.ncbi.nlm.nih.gov/pubmed/26859456
http://dx.doi.org/10.1016/j.ccell.2016.01.002

Διαδίκτυο

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749542/
https://www.ncbi.nlm.nih.gov/pubmed/26859456
http://dx.doi.org/10.1016/j.ccell.2016.01.002

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