Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

Integrins require an activation step prior to ligand binding and signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we report that fibroblasts lacking either talin or kindlin failed to activate β1 integrins, adhere to fibronectin (FN) or...

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Detalles Bibliográficos
Autores principales: Theodosiou, Marina, Widmaier, Moritz, Böttcher, Ralph T, Rognoni, Emanuel, Veelders, Maik, Bharadwaj, Mitasha, Lambacher, Armin, Austen, Katharina, Müller, Daniel J, Zent, Roy, Fässler, Reinhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749545/
https://www.ncbi.nlm.nih.gov/pubmed/26821125
http://dx.doi.org/10.7554/eLife.10130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749545/
https://www.ncbi.nlm.nih.gov/pubmed/26821125
http://dx.doi.org/10.7554/eLife.10130

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