A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit, Lamb1

A new mutant mouse (lamb1t) exhibits intermittent dystonic hindlimb movements and postures when awake, and hyperextension when asleep. Experiments showed co-contraction of opposing muscle groups, and indicated that symptoms depended on the interaction of brain and spinal cord. SNP mapping and exome...

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Detalles Bibliográficos
Autores principales: Liu, Yi Bessie, Tewari, Ambika, Salameh, Johnny, Arystarkhova, Elena, Hampton, Thomas G, Brashear, Allison, Ozelius, Laurie J, Khodakhah, Kamran, Sweadner, Kathleen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749547/
https://www.ncbi.nlm.nih.gov/pubmed/26705335
http://dx.doi.org/10.7554/eLife.11102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749547/
https://www.ncbi.nlm.nih.gov/pubmed/26705335
http://dx.doi.org/10.7554/eLife.11102

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