Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis

Glutaminase (GLS) isoenzymes GLS1 and GLS2 are key enzymes for glutamine metabolism. Interestingly, GLS1 and GLS2 display contrasting functions in tumorigenesis with elusive mechanism; GLS1 promotes tumorigenesis, whereas GLS2 exhibits a tumor-suppressive function. In this study, we found that GLS2...

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Detalles Bibliográficos
Autores principales: Zhang, Cen, Liu, Juan, Zhao, Yuhan, Yue, Xuetian, Zhu, Yu, Wang, Xiaolong, Wu, Hao, Blanco, Felix, Li, Shaohua, Bhanot, Gyan, Haffty, Bruce G, Hu, Wenwei, Feng, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749555/
https://www.ncbi.nlm.nih.gov/pubmed/26751560
http://dx.doi.org/10.7554/eLife.10727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749555/
https://www.ncbi.nlm.nih.gov/pubmed/26751560
http://dx.doi.org/10.7554/eLife.10727

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