TGFβ-dependent expression of PD-1 and PD-L1 controls CD8(+) T cell anergy in transplant tolerance

CD8(+) T cell anergy is a critical mechanism of peripheral tolerance, poorly investigated in response to immunotherapy. Here, using a pancreatic islet allograft model and CD3 antibody therapy, we showed, by single cell gene profiling, that intragraft CD8(+) lymphocytes coexpressing granzyme B and pe...

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Detalles Bibliográficos
Autores principales: Baas, Marije, Besançon, Alix, Goncalves, Tania, Valette, Fabrice, Yagita, Hideo, Sawitzki, Birgit, Volk, Hans-Dieter, Waeckel-Enée, Emmanuelle, Rocha, Benedita, Chatenoud, Lucienne, You, Sylvaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749558/
https://www.ncbi.nlm.nih.gov/pubmed/26824266
http://dx.doi.org/10.7554/eLife.08133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749558/
https://www.ncbi.nlm.nih.gov/pubmed/26824266
http://dx.doi.org/10.7554/eLife.08133

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