Unravelling druggable signalling networks that control F508del-CFTR proteostasis

Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator (CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is, in the misfolding and intracellular degradation of the protein. The F508del-CFTR proteostasis machinery and its homeostati...

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Detalles Bibliográficos
Autores principales: Hegde, Ramanath Narayana, Parashuraman, Seetharaman, Iorio, Francesco, Ciciriello, Fabiana, Capuani, Fabrizio, Carissimo, Annamaria, Carrella, Diego, Belcastro, Vincenzo, Subramanian, Advait, Bounti, Laura, Persico, Maria, Carlile, Graeme, Galietta, Luis, Thomas, David Y, Di Bernardo, Diego, Luini, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749566/
https://www.ncbi.nlm.nih.gov/pubmed/26701908
http://dx.doi.org/10.7554/eLife.10365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749566/
https://www.ncbi.nlm.nih.gov/pubmed/26701908
http://dx.doi.org/10.7554/eLife.10365

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