Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression

JAK2V617F(+) myeloproliferative neoplasms (MPNs) frequently progress into leukemias, but the factors driving this process are not understood. Here, we find excess Hedgehog (HH) ligand secretion and loss of PTCH2 in myeloproliferative disease, which drives canonical and noncanonical HH-signaling. Int...

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Detalles Bibliográficos
Autores principales: Klein, Claudius, Zwick, Anabel, Kissel, Sandra, Forster, Christine Ulrike, Pfeifer, Dietmar, Follo, Marie, Illert, Anna Lena, Decker, Sarah, Benkler, Thomas, Pahl, Heike, Oostendorp, Robert A.J., Aumann, Konrad, Duyster, Justus, Dierks, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749921/
https://www.ncbi.nlm.nih.gov/pubmed/26834157
http://dx.doi.org/10.1084/jem.20150556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749921/
https://www.ncbi.nlm.nih.gov/pubmed/26834157
http://dx.doi.org/10.1084/jem.20150556

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