Cargando…

Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression

JAK2V617F(+) myeloproliferative neoplasms (MPNs) frequently progress into leukemias, but the factors driving this process are not understood. Here, we find excess Hedgehog (HH) ligand secretion and loss of PTCH2 in myeloproliferative disease, which drives canonical and noncanonical HH-signaling. Int...

Descripción completa

Detalles Bibliográficos
Autores principales:	Klein, Claudius, Zwick, Anabel, Kissel, Sandra, Forster, Christine Ulrike, Pfeifer, Dietmar, Follo, Marie, Illert, Anna Lena, Decker, Sarah, Benkler, Thomas, Pahl, Heike, Oostendorp, Robert A.J., Aumann, Konrad, Duyster, Justus, Dierks, Christine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749921/ https://www.ncbi.nlm.nih.gov/pubmed/26834157 http://dx.doi.org/10.1084/jem.20150556

Ejemplares similares

Optimized Xenograft Protocol for Chronic Lymphocytic Leukemia Results in High Engraftment Efficiency for All CLL Subgroups
por: Decker, Sarah, et al.
Publicado: (2019)

Oncogenic Kras(G12D) causes myeloproliferation via NLRP3 inflammasome activation
por: Hamarsheh, Shaima’a, et al.
Publicado: (2020)

Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction
por: Verboon, Jeffrey M., et al.
Publicado: (2020)

Current Immunotherapeutic Approaches in T Cell Non-Hodgkin Lymphomas
por: Poggio, Teresa, et al.
Publicado: (2018)

Depletion of STAT5 blocks TEL–SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice
por: Sprissler, C, et al.
Publicado: (2014)

Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation
por: Thiel, V N, et al.
Publicado: (2017)

Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation
por: Villatoro, Alicia, et al.
Publicado: (2023)

First-in-human study of WT1 recombinant protein vaccination in elderly patients with AML in remission: a single-center experience
por: Kreutmair, Stefanie, et al.
Publicado: (2022)

Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation
por: Tripodo, Claudio, et al.
Publicado: (2022)

APC/C(Cdh1)-Mediated Degradation of the F-Box Protein NIPA Is Regulated by Its Association with Skp1
por: von Klitzing, Christine, et al.
Publicado: (2011)

miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
por: Boldin, Mark P., et al.
Publicado: (2011)

Early Lineage Priming by Trisomy of Erg Leads to Myeloproliferation in a Down Syndrome Model
por: Ng, Ashley P., et al.
Publicado: (2015)

Author Correction: Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation
por: Villatoro, Alicia, et al.
Publicado: (2023)

Murine Oncostatin M Has Opposing Effects on the Proliferation of OP9 Bone Marrow Stromal Cells and NIH/3T3 Fibroblasts Signaling through the OSMR
por: Jakob, Lena, et al.
Publicado: (2021)

Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) mice
por: Kang, Hio Chung, et al.
Publicado: (2012)

Different Response of Ptch Mutant and Ptch Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors
por: Geyer, Natalie, et al.
Publicado: (2018)

Dnmt3a Regulates Myeloproliferation and Liver-Specific Expansion of Hematopoietic Stem and Progenitor Cells
por: Guryanova, Olga A., et al.
Publicado: (2015)

Development of Highly Sensitive Digital Droplet PCR for Detection of cKIT Mutations in Circulating Free DNA That Mediate Resistance to TKI Treatment for Gastrointestinal Stromal Tumor (GIST)
por: Rassner, Michael, et al.
Publicado: (2023)

A Knock-In Npm1 Mutation in Mice Results in Myeloproliferation and Implies a Perturbation in Hematopoietic Microenvironment
por: Chou, Shiu-Huey, et al.
Publicado: (2012)

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD–induced myeloproliferation
por: Mead, Adam J., et al.
Publicado: (2017)

Proteasome inhibition enhances the efficacy of volasertib-induced mitotic arrest in AML in vitro and prolongs survival in vivo
por: Schnerch, Dominik, et al.
Publicado: (2017)

Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
por: Kim, Yeonjoo, et al.
Publicado: (2020)

A20 deficiency in hematopoietic stem cells causes lymphopenia and myeloproliferation due to elevated Interferon-γ signals
por: Nakagawa, Masahiro Marshall, et al.
Publicado: (2019)

TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia
por: Szenes, Eva, et al.
Publicado: (2020)

Role of PTCH1 gene methylation in gastric carcinogenesis
por: ZUO, YUN, et al.
Publicado: (2014)

Unexpected phenotype in a frameshift mutation of PTCH1
por: Beltrami, Benedetta, et al.
Publicado: (2019)

Combination of Lenvatinib and Pembrolizumab Is an Effective Treatment Option for Anaplastic and Poorly Differentiated Thyroid Carcinoma
por: Dierks, Christine, et al.
Publicado: (2021)

A healthy individual with a homozygous PTCH2 frameshift variant: Are variants of PTCH2 associated with nevoid basal cell carcinoma syndrome?
por: Altaraihi, M., et al.
Publicado: (2019)

Author Correction: Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration
por: Kim, Yeonjoo, et al.
Publicado: (2020)

Microenvironmental stromal cells abrogate NF-κB inhibitor-induced apoptosis in chronic lymphocytic leukemia
por: Simon-Gabriel, Carl Philipp, et al.
Publicado: (2018)

Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia
por: Yu, Chuanjiang, et al.
Publicado: (2020)

Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferation in mice via altered Runx1 splicing
por: Aitken, Marisa J L, et al.
Publicado: (2022)

Biallelic deleterious germline SH2B3 variants cause a novel syndrome of myeloproliferation and multi‐organ autoimmunity
por: Blombery, Piers, et al.
Publicado: (2023)

Targeting the Multidrug Transporter Ptch1 Potentiates Chemotherapy Efficiency
por: Hasanovic, Anida, et al.
Publicado: (2018)

Mutation of the PTCH1 gene predicts recurrence of breast cancer
por: Wang, Chih-Yang, et al.
Publicado: (2019)

Ptch2 is a Potential Regulator of Mesenchymal Stem Cells
por: Juuri, Emma, et al.
Publicado: (2022)

Personalized Treatment Selection and Disease Monitoring Using Circulating Tumor DNA Profiling in Real-World Cancer Patient Management
por: Wehrle, Julius, et al.
Publicado: (2020)

Monitoring of Measurable Residual Disease Using Circulating DNA after Allogeneic Hematopoietic Cell Transplantation
por: Waterhouse, Miguel, et al.
Publicado: (2022)

A novel PTCH1 mutation in a patient with Gorlin syndrome
por: Okamoto, Nana, et al.
Publicado: (2014)

New mutations and an updated database for the patched‐1 (PTCH1) gene
por: Reinders, Marie G., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ojcrfaaqjnjab68lkqcvh6v7ce