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Metabolic disruption identified in the Huntington’s disease transgenic sheep model
Huntington’s disease (HD) is a dominantly inherited, progressive neurodegenerative disorder caused by a CAG repeat expansion within exon 1 of HTT, encoding huntingtin. There are no therapies that can delay the progression of this devastating disease. One feature of HD that may play a critical role i...
Autores principales: | Handley, Renee. R., Reid, Suzanne J., Patassini, Stefano, Rudiger, Skye R., Obolonkin, Vladimir, McLaughlan, Clive. J., Jacobsen, Jessie C., Gusella, James F., MacDonald, Marcy E., Waldvogel, Henry J., Bawden, C. Simon, Faull, Richard L. M., Snell, Russell G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749952/ https://www.ncbi.nlm.nih.gov/pubmed/26864449 http://dx.doi.org/10.1038/srep20681 |
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