New insights into the mechanism of substrates trafficking in Glyoxylate/Hydroxypyruvate reductases

Glyoxylate accumulation within cells is highly toxic. In humans, it is associated with hyperoxaluria type 2 (PH2) leading to renal failure. The glyoxylate content within cells is regulated by the NADPH/NADH dependent glyoxylate/hydroxypyruvate reductases (GRHPR). These are highly conserved enzymes w...

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Detalles Bibliográficos
Autores principales: Lassalle, Louise, Engilberge, Sylvain, Madern, Dominique, Vauclare, Pierre, Franzetti, Bruno, Girard, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749974/
https://www.ncbi.nlm.nih.gov/pubmed/26865263
http://dx.doi.org/10.1038/srep20629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749974/
https://www.ncbi.nlm.nih.gov/pubmed/26865263
http://dx.doi.org/10.1038/srep20629

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