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New insights into the mechanism of substrates trafficking in Glyoxylate/Hydroxypyruvate reductases

Glyoxylate accumulation within cells is highly toxic. In humans, it is associated with hyperoxaluria type 2 (PH2) leading to renal failure. The glyoxylate content within cells is regulated by the NADPH/NADH dependent glyoxylate/hydroxypyruvate reductases (GRHPR). These are highly conserved enzymes w...

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Detalles Bibliográficos
Autores principales:	Lassalle, Louise, Engilberge, Sylvain, Madern, Dominique, Vauclare, Pierre, Franzetti, Bruno, Girard, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749974/ https://www.ncbi.nlm.nih.gov/pubmed/26865263 http://dx.doi.org/10.1038/srep20629

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