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Selective binding modes and allosteric inhibitory effects of lupane triterpenes on protein tyrosine phosphatase 1B
Protein Tyrosine Phosphatase 1B (PTP1B) has been recognized as a promising therapeutic target for treating obesity, diabetes, and certain cancers for over a decade. Previous drug design has focused on inhibitors targeting the active site of PTP1B. However, this has not been successful because the ac...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749975/ https://www.ncbi.nlm.nih.gov/pubmed/26865097 http://dx.doi.org/10.1038/srep20766 |