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Intrinsic and membrane-facilitated α-synuclein oligomerization revealed by label-free detection through solid-state nanopores
α-Synuclein (α-Syn) is an abundant cytosolic protein involved in the release of neurotransmitters in presynaptic terminal and its aberrant aggregation is found to be associated with Parkinson’s disease. Recent study suggests that the oligomers formed at the initial oligomerization stage may be the r...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749980/ https://www.ncbi.nlm.nih.gov/pubmed/26865505 http://dx.doi.org/10.1038/srep20776 |