Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells

Prions are proteinaceous infectious particles which cause fatal neurodegenerative disorders in humans and animals. They consist of a mostly β-sheeted aggregated isoform (PrP(Sc)) of the cellular prion protein (PrP(c)). Prions replicate autocatalytically in neurons and other cell types by inducing co...

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Detalles Bibliográficos
Autores principales: Shim, Su Yeon, Karri, Srinivasarao, Law, Sampson, Schatzl, Hermann M., Gilch, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749993/
https://www.ncbi.nlm.nih.gov/pubmed/26865414
http://dx.doi.org/10.1038/srep21658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749993/
https://www.ncbi.nlm.nih.gov/pubmed/26865414
http://dx.doi.org/10.1038/srep21658

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