Progranulin suppresses titanium particle induced inflammatory osteolysis by targeting TNFα signaling

Aseptic loosening is a major complication of prosthetic joint surgery, characterized by chronic inflammation, pain, and osteolysis surrounding the bone-implant interface. Progranulin (PGRN) is known to have anti-inflammatory action by binding to Tumor Necrosis Factor (TNF) receptors and antagonizing...

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Detalles Bibliográficos
Autores principales: Zhao, Yun-peng, Wei, Jian-lu, Tian, Qing-yun, Liu, Alexander Tianxing, Yi, Young-Su, Einhorn, Thomas A., Liu, Chuan-ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750042/
https://www.ncbi.nlm.nih.gov/pubmed/26864916
http://dx.doi.org/10.1038/srep20909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750042/
https://www.ncbi.nlm.nih.gov/pubmed/26864916
http://dx.doi.org/10.1038/srep20909

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