Cargando…

Progranulin suppresses titanium particle induced inflammatory osteolysis by targeting TNFα signaling

Aseptic loosening is a major complication of prosthetic joint surgery, characterized by chronic inflammation, pain, and osteolysis surrounding the bone-implant interface. Progranulin (PGRN) is known to have anti-inflammatory action by binding to Tumor Necrosis Factor (TNF) receptors and antagonizing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Yun-peng, Wei, Jian-lu, Tian, Qing-yun, Liu, Alexander Tianxing, Yi, Young-Su, Einhorn, Thomas A., Liu, Chuan-ju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750042/ https://www.ncbi.nlm.nih.gov/pubmed/26864916 http://dx.doi.org/10.1038/srep20909

Ejemplares similares

Britanin inhibits titanium wear particle‑induced osteolysis and osteoclastogenesis
por: Kim, Ju Ang, et al.
Publicado: (2023)

Mechanism and Prevention of Titanium Particle-Induced Inflammation and Osteolysis
por: Eger, Michal, et al.
Publicado: (2018)

The Inhibition of RANKL-Induced Osteoclastogenesis through the Suppression of p38 Signaling Pathway by Naringenin and Attenuation of Titanium-Particle-Induced Osteolysis
por: Wang, Wengang, et al.
Publicado: (2014)

Serum progranulin to TNF-α ratio in patients with gonarthrosis
por: Yıldız, Kadri, et al.
Publicado: (2021)

Lonafarnib Inhibits Farnesyltransferase via Suppressing ERK Signaling Pathway to Prevent Osteoclastogenesis in Titanium Particle-Induced Osteolysis
por: Huang, Linke, et al.
Publicado: (2022)

Kaempferide Prevents Titanium Particle Induced Osteolysis by Suppressing JNK Activation during Osteoclast Formation
por: Jiao, Zixian, et al.
Publicado: (2017)

Tetrandrine Inhibits Titanium Particle-Induced Inflammatory Osteolysis through the Nuclear Factor-κB Pathway
por: Liu, Zige, et al.
Publicado: (2020)

Progranulin derived engineered protein Atsttrin suppresses TNF-α-mediated inflammation in intervertebral disc degenerative disease
por: Ding, Hong, et al.
Publicado: (2017)

Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice
por: Zhao, Yun-peng, et al.
Publicado: (2015)

Adenovirus-Mediated siRNA Targeting CXCR2 Attenuates Titanium Particle-Induced Osteolysis by Suppressing Osteoclast Formation
por: Wang, Chen, et al.
Publicado: (2016)

Anti-TNF-α therapy as a clinical intervention for periprosthetic osteolysis
por: Schwarz, Edward M, et al.
Publicado: (2000)

Magnoflorine Suppresses MAPK and NF-κB Signaling to Prevent Inflammatory Osteolysis Induced by Titanium Particles In Vivo and Osteoclastogenesis via RANKL In Vitro
por: Sun, Zhenyu, et al.
Publicado: (2020)

YB-1 Interferes with TNFα–TNFR Binding and Modulates Progranulin-Mediated Inhibition of TNFα Signaling
por: Hessman, Christopher L., et al.
Publicado: (2020)

Piperlongumine Inhibits Titanium Particles-Induced Osteolysis, Osteoclast Formation, and RANKL-Induced Signaling Pathways
por: Liu, Xuan, et al.
Publicado: (2022)

Metformin suppresses UHMWPE particle-induced osteolysis in the mouse calvaria by promoting polarization of macrophages to an anti-inflammatory phenotype
por: Yan, Zhao, et al.
Publicado: (2018)

Lycorine suppresses RANKL-induced osteoclastogenesis in vitro and prevents ovariectomy-induced osteoporosis and titanium particle-induced osteolysis in vivo
por: Chen, Shuai, et al.
Publicado: (2015)

HUCMSC‐derived Exosomes Suppress the Titanium Particles‐induced Osteolysis in Mice through Inhibiting CCL2 and CCL3
por: Li, Shixun, et al.
Publicado: (2023)

Inhibitory effect of quercetin on titanium particle induced endoplasmic reticulum stress related apoptosis and in vivo osteolysis
por: Zhang, Laibo, et al.
Publicado: (2017)

Effects of the Local Bone Renin-Angiotensin System on Titanium-Particle-Induced Periprosthetic Osteolysis
por: Zhao, Zhiping, et al.
Publicado: (2021)

GSK-3β suppression upregulates Gli1 to alleviate osteogenesis inhibition in titanium nanoparticle-induced osteolysis
por: Wang, Qing, et al.
Publicado: (2022)

Inhibition of RANKL- induced osteoclastogenesis through the suppression of the ERK signaling pathway by astragaloside IV and attenuation of titanium- particle- induced osteolysis
Publicado: (2018)

Puerarin inhibits titanium particle‐induced osteolysis and RANKL‐induced osteoclastogenesis via suppression of the NF‐κB signaling pathway
por: Tang, Wenkai, et al.
Publicado: (2020)

Imbalance between TNFα and progranulin contributes to memory impairment and anxiety in sleep-deprived mice
por: Zhang, Kun, et al.
Publicado: (2017)

Progranulin Facilitates Conversion and Function of Regulatory T Cells under Inflammatory Conditions
por: Wei, Fanhua, et al.
Publicado: (2014)

SPHK Inhibitors and Zoledronic Acid Suppress Osteoclastogenesis and Wear Particle-Induced Osteolysis
por: Gu, Minghui, et al.
Publicado: (2022)

20(S)-Protopanaxadiol Inhibits Titanium Particle-Induced Inflammatory Osteolysis and RANKL-Mediated Osteoclastogenesis via MAPK and NF-κB Signaling Pathways
por: Pan, Chenhao, et al.
Publicado: (2019)

Scaling of titanium implants entrains inflammation-induced osteolysis
por: Eger, Michal, et al.
Publicado: (2017)

Association Between Progranulin and Gaucher Disease
por: Jian, Jinlong, et al.
Publicado: (2016)

Titanium Wear Particles Exacerbate S. epidermidis-Induced Implant-Related Osteolysis and Decrease Efficacy of Antibiotic Therapy
por: Siverino, Claudia, et al.
Publicado: (2021)

Puerarin Exerts Protective Effects on Wear Particle-Induced Inflammatory Osteolysis
por: Yang, Chao, et al.
Publicado: (2019)

Jatrorrhizine Hydrochloride Suppresses RANKL-Induced Osteoclastogenesis and Protects against Wear Particle-Induced Osteolysis
por: Li, Hui, et al.
Publicado: (2018)

Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease
por: Jian, Jinlong, et al.
Publicado: (2016)

Osteoclasts; culprits in inflammatory osteolysis
por: Teitelbaum, Steven L
Publicado: (2006)

Curculigoside Protects against Titanium Particle-Induced Osteolysis through the Enhancement of Osteoblast Differentiation and Reduction of Osteoclast Formation
por: Zhu, Fangbing, et al.
Publicado: (2021)

Genetic and pharmacological activation of Hedgehog signaling inhibits osteoclastogenesis and attenuates titanium particle-induced osteolysis partly through suppressing the JNK/c-Fos-NFATc1 cascade
por: Zhang, Liwei, et al.
Publicado: (2020)

Stevioside Prevents Wear Particle-Induced Osteolysis by Inhibiting Osteoclastogenesis and Inflammatory Response via the Suppression of TAK1 Activation
por: Meng, Jiahong, et al.
Publicado: (2018)

Celastrol Attenuates RANKL-Induced Osteoclastogenesis in vitro and Reduces Titanium Particle-Induced Osteolysis and Ovariectomy-Induced Bone Loss in vivo
por: Xu, Qiang, et al.
Publicado: (2021)

Chrysin Protects Against Titanium Particle-Induced Osteolysis by Attenuating Osteoclast Formation and Function by Inhibiting NF-κB and MAPK Signaling
por: Wu, Zuoxing, et al.
Publicado: (2022)

Mechanical instability and titanium particles induce similar transcriptomic changes in a rat model for periprosthetic osteolysis and aseptic loosening
por: Amirhosseini, Mehdi, et al.
Publicado: (2017)

The effect of strontium ranelate on titanium particle-induced periprosthetic osteolysis regulated by WNT/β-catenin signaling in vivo and in vitro
por: Wang, Bolun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_r09n8uimt019pc58tfe8hse9v9