Executive function in adolescents with PKU and their siblings: Associations with biochemistry

Previous research shows consistent and marked executive function impairment in children with early and continuously treated phenylketonuria. This between groups analysis (phenylketonuria group vs sibling controls) found no significant differences in executive function (although adolescents with phen...

Descripción completa

Detalles Bibliográficos
Autores principales: Sharman, R., Sullivan, K., Young, R., McGill, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750585/
https://www.ncbi.nlm.nih.gov/pubmed/26937416
http://dx.doi.org/10.1016/j.ymgmr.2015.08.001
_version_ 1782415457307852800
author Sharman, R.
Sullivan, K.
Young, R.
McGill, J.
author_facet Sharman, R.
Sullivan, K.
Young, R.
McGill, J.
author_sort Sharman, R.
collection PubMed
description Previous research shows consistent and marked executive function impairment in children with early and continuously treated phenylketonuria. This between groups analysis (phenylketonuria group vs sibling controls) found no significant differences in executive function (although adolescents with phenylketonuria performed slightly worse than their siblings). Biochemical relationships with executive function were confined to long-term measures of high phenylalanine:tyrosine ratio exposure, as well as tyrosine exposure independent of phenylalanine. This study suggests that early and continuously treated PKU results in non-significant EF differences (compared to siblings), although the influence of long-term exposure to poorer metabolic control is still evident.
format Online
Article
Text
id pubmed-4750585
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-47505852016-03-02 Executive function in adolescents with PKU and their siblings: Associations with biochemistry Sharman, R. Sullivan, K. Young, R. McGill, J. Mol Genet Metab Rep Short Communication Previous research shows consistent and marked executive function impairment in children with early and continuously treated phenylketonuria. This between groups analysis (phenylketonuria group vs sibling controls) found no significant differences in executive function (although adolescents with phenylketonuria performed slightly worse than their siblings). Biochemical relationships with executive function were confined to long-term measures of high phenylalanine:tyrosine ratio exposure, as well as tyrosine exposure independent of phenylalanine. This study suggests that early and continuously treated PKU results in non-significant EF differences (compared to siblings), although the influence of long-term exposure to poorer metabolic control is still evident. Elsevier 2015-08-24 /pmc/articles/PMC4750585/ /pubmed/26937416 http://dx.doi.org/10.1016/j.ymgmr.2015.08.001 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Short Communication
Sharman, R.
Sullivan, K.
Young, R.
McGill, J.
Executive function in adolescents with PKU and their siblings: Associations with biochemistry
title Executive function in adolescents with PKU and their siblings: Associations with biochemistry
title_full Executive function in adolescents with PKU and their siblings: Associations with biochemistry
title_fullStr Executive function in adolescents with PKU and their siblings: Associations with biochemistry
title_full_unstemmed Executive function in adolescents with PKU and their siblings: Associations with biochemistry
title_short Executive function in adolescents with PKU and their siblings: Associations with biochemistry
title_sort executive function in adolescents with pku and their siblings: associations with biochemistry
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750585/
https://www.ncbi.nlm.nih.gov/pubmed/26937416
http://dx.doi.org/10.1016/j.ymgmr.2015.08.001
work_keys_str_mv AT sharmanr executivefunctioninadolescentswithpkuandtheirsiblingsassociationswithbiochemistry
AT sullivank executivefunctioninadolescentswithpkuandtheirsiblingsassociationswithbiochemistry
AT youngr executivefunctioninadolescentswithpkuandtheirsiblingsassociationswithbiochemistry
AT mcgillj executivefunctioninadolescentswithpkuandtheirsiblingsassociationswithbiochemistry