Executive function in adolescents with PKU and their siblings: Associations with biochemistry
Previous research shows consistent and marked executive function impairment in children with early and continuously treated phenylketonuria. This between groups analysis (phenylketonuria group vs sibling controls) found no significant differences in executive function (although adolescents with phen...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750585/ https://www.ncbi.nlm.nih.gov/pubmed/26937416 http://dx.doi.org/10.1016/j.ymgmr.2015.08.001 |
_version_ | 1782415457307852800 |
---|---|
author | Sharman, R. Sullivan, K. Young, R. McGill, J. |
author_facet | Sharman, R. Sullivan, K. Young, R. McGill, J. |
author_sort | Sharman, R. |
collection | PubMed |
description | Previous research shows consistent and marked executive function impairment in children with early and continuously treated phenylketonuria. This between groups analysis (phenylketonuria group vs sibling controls) found no significant differences in executive function (although adolescents with phenylketonuria performed slightly worse than their siblings). Biochemical relationships with executive function were confined to long-term measures of high phenylalanine:tyrosine ratio exposure, as well as tyrosine exposure independent of phenylalanine. This study suggests that early and continuously treated PKU results in non-significant EF differences (compared to siblings), although the influence of long-term exposure to poorer metabolic control is still evident. |
format | Online Article Text |
id | pubmed-4750585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-47505852016-03-02 Executive function in adolescents with PKU and their siblings: Associations with biochemistry Sharman, R. Sullivan, K. Young, R. McGill, J. Mol Genet Metab Rep Short Communication Previous research shows consistent and marked executive function impairment in children with early and continuously treated phenylketonuria. This between groups analysis (phenylketonuria group vs sibling controls) found no significant differences in executive function (although adolescents with phenylketonuria performed slightly worse than their siblings). Biochemical relationships with executive function were confined to long-term measures of high phenylalanine:tyrosine ratio exposure, as well as tyrosine exposure independent of phenylalanine. This study suggests that early and continuously treated PKU results in non-significant EF differences (compared to siblings), although the influence of long-term exposure to poorer metabolic control is still evident. Elsevier 2015-08-24 /pmc/articles/PMC4750585/ /pubmed/26937416 http://dx.doi.org/10.1016/j.ymgmr.2015.08.001 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Short Communication Sharman, R. Sullivan, K. Young, R. McGill, J. Executive function in adolescents with PKU and their siblings: Associations with biochemistry |
title | Executive function in adolescents with PKU and their siblings: Associations with biochemistry |
title_full | Executive function in adolescents with PKU and their siblings: Associations with biochemistry |
title_fullStr | Executive function in adolescents with PKU and their siblings: Associations with biochemistry |
title_full_unstemmed | Executive function in adolescents with PKU and their siblings: Associations with biochemistry |
title_short | Executive function in adolescents with PKU and their siblings: Associations with biochemistry |
title_sort | executive function in adolescents with pku and their siblings: associations with biochemistry |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750585/ https://www.ncbi.nlm.nih.gov/pubmed/26937416 http://dx.doi.org/10.1016/j.ymgmr.2015.08.001 |
work_keys_str_mv | AT sharmanr executivefunctioninadolescentswithpkuandtheirsiblingsassociationswithbiochemistry AT sullivank executivefunctioninadolescentswithpkuandtheirsiblingsassociationswithbiochemistry AT youngr executivefunctioninadolescentswithpkuandtheirsiblingsassociationswithbiochemistry AT mcgillj executivefunctioninadolescentswithpkuandtheirsiblingsassociationswithbiochemistry |