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Mesoglycan attenuates VSMC proliferation through activation of AMP-activated protein kinase and mTOR

BACKGROUND: Vascular smooth muscle cells (VSMC) proliferation contributes significantly to intimal thickening in atherosclerosis and restenosis diseases. Platelet derived growth factor (PDGF) has been implicated in VSMC proliferation though the activation of multiple growth-promoting signals. Mesogl...

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Detalles Bibliográficos
Autores principales: Lee, Kyung Young, Lee, Dong Hyup, Choi, Hyoung Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750809/
https://www.ncbi.nlm.nih.gov/pubmed/26893937
http://dx.doi.org/10.1186/s40885-016-0037-x