Cargando…

Mesoglycan attenuates VSMC proliferation through activation of AMP-activated protein kinase and mTOR

BACKGROUND: Vascular smooth muscle cells (VSMC) proliferation contributes significantly to intimal thickening in atherosclerosis and restenosis diseases. Platelet derived growth factor (PDGF) has been implicated in VSMC proliferation though the activation of multiple growth-promoting signals. Mesogl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Kyung Young, Lee, Dong Hyup, Choi, Hyoung Chul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750809/ https://www.ncbi.nlm.nih.gov/pubmed/26893937 http://dx.doi.org/10.1186/s40885-016-0037-x

Ejemplares similares

Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling
por: Xie, Hao, et al.
Publicado: (2020)

Activation of AMPK by Telmisartan Decreases Basal and PDGF-stimulated VSMC Proliferation via Inhibiting the mTOR/p70S6K Signaling Axis
por: Hwang, Yun-Jin, et al.
Publicado: (2020)

mTOR coordinates protein synthesis, mitochondrial activity and proliferation
por: Morita, Masahiro, et al.
Publicado: (2015)

Mesoglycan: Clinical Evidences for Use in Vascular Diseases
por: Tufano, Antonella, et al.
Publicado: (2010)

Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS/NFκB/mTOR/P70S6K signaling cascade
por: Lu, Qing-Bo, et al.
Publicado: (2017)

Inhibition of Connexin 43 reverses ox-LDL-mediated inhibition of autophagy in VSMC by inhibiting the PI3K/Akt/mTOR signaling pathway
por: Qin, Xuqing, et al.
Publicado: (2022)

Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts
por: Storozhuk, Yaryna, et al.
Publicado: (2012)

NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension
por: Sun, Hai-Jian, et al.
Publicado: (2017)

mTOR-Dependent Cell Proliferation in the Brain
por: Ryskalin, Larisa, et al.
Publicado: (2017)

Inhibition of Mast Cell Function and Proliferation by mTOR Activator MHY1485
por: Rakhmanova, Valeriya, et al.
Publicado: (2018)

PCL/Mesoglycan Devices Obtained by Supercritical Foaming and Impregnation
por: Franco, Paola, et al.
Publicado: (2019)

mTOR and its link to the picture of Dorian Gray - re-activation of mTOR promotes aging
por: Węsierska-Gądek, Józefa
Publicado: (2010)

In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against Leishmania donovani and Trypanosoma brucei
por: Phan, Trong-Nhat, et al.
Publicado: (2020)

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity
por: Xie, Jianling, et al.
Publicado: (2011)

Three generations of mTOR kinase inhibitors in the activation of the apoptosis process in melanoma cells
por: Ciołczyk-Wierzbicka, Dorota, et al.
Publicado: (2023)

mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance
por: Woo, Yunseo, et al.
Publicado: (2019)

mTOR/PRAS40 interaction: Hypertrophy or proliferation
por: Völkers, Mirko, et al.
Publicado: (2013)

All PI3Kinase signaling is not mTOR: dissecting mTOR-dependent and independent signaling pathways in T cells
por: Gamper, Christopher J., et al.
Publicado: (2012)

mTOR Signaling Cascade in Psoriatic Disease: Double Kinase mTOR Inhibitor a Novel Therapeutic Target
por: Raychaudhuri, Smriti K, et al.
Publicado: (2014)

Assessment of the effect of mesoglycan in the treatment of audiovestibular disorders of vascular origin
por: Neri, Giampiero, et al.
Publicado: (2018)

Production of Mesoglycan/PCL Based Composites through Supercritical Impregnation
por: Liparoti, Sara, et al.
Publicado: (2022)

mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis
por: Bao, Yi, et al.
Publicado: (2015)

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53
por: Jung, Seung Hee, et al.
Publicado: (2018)

The mTOR kinase inhibitors polarize glioma-activated microglia to express a M1 phenotype
por: Lisi, Lucia, et al.
Publicado: (2014)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

Anti-proliferative Effect of 15,16-Dihydrotanshinone I Through Cell Cycle Arrest and the Regulation of AMP-activated Protein Kinase/Akt/mTOR and Mitogen-activated Protein Kinase Signaling Pathway in Human Hepatocellular Carcinoma Cells
por: Hong, Ji-Young, et al.
Publicado: (2018)

Activated mTOR signaling pathway in myofibers with inherited metabolic defect might be an evidence for mTOR inhibition therapies
por: Lyu, Jing-Wei, et al.
Publicado: (2019)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

Activation of mTOR: a culprit of Alzheimer’s disease?
por: Cai, Zhiyou, et al.
Publicado: (2015)

Activation of mTOR Signaling Pathway in Hepatocellular Carcinoma
por: Ferrín, Gustavo, et al.
Publicado: (2020)

mTOR regulates GPVI-mediated platelet activation
por: Wang, Longsheng, et al.
Publicado: (2021)

CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation
por: Shuda, Masahiro, et al.
Publicado: (2015)

Correction to: Three generations of mTOR kinase inhibitors in the activation of the apoptosis process in melanoma cells
por: Ciołczyk-Wierzbicka, Dorota, et al.
Publicado: (2023)

Activation of Calcium-Sensing Receptor increases intracellular calcium and decreases cAMP and mTOR in PKD1 deficient cells
por: Di Mise, Annarita, et al.
Publicado: (2018)

Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner
por: Debnath, Jayanta, et al.
Publicado: (2003)

Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration
por: Nguyen, Joe Truong, et al.
Publicado: (2018)

TFE3 regulates renal adenocarcinoma cell proliferation via activation of the mTOR pathway
por: Fang, Yuan, et al.
Publicado: (2017)

CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling
por: Yu, Shijun, et al.
Publicado: (2021)

The phosphatidylinositol-3 kinase/mTOR pathway: new agents
por: Arteaga, CL
Publicado: (2011)

Chemical and Structural Strategies to Selectively Target mTOR Kinase
por: Borsari, Chiara, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dh7chtpet8br7g7enc5fqggk39