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Epigenetics, TET proteins, and hypoxia in epithelial-mesenchymal transition and tumorigenesis

Hypoxia in tumors is primarily a pathophysiologic consequence of structurally and functionally disturbed microcirculation with inadequate supply of oxygen. Tumor hypoxia is strongly associated with tumor propagation, malignant progression, and resistance to therapy. Aberrant epigenetic regulation pl...

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Detalles Bibliográficos
Autores principales: Chen, Hsiao-Fan, Wu, Kou-Juey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: China Medical University 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751095/
https://www.ncbi.nlm.nih.gov/pubmed/26869355
http://dx.doi.org/10.7603/s40681-016-0001-9