Strong Constraint on Human Genes Escaping X-Inactivation Is Modulated by their Expression Level and Breadth in Both Sexes

In eutherian mammals, X-linked gene expression is normalized between XX females and XY males through the process of X chromosome inactivation (XCI). XCI results in silencing of transcription from one ChrX homolog per female cell. However, approximately 25% of human ChrX genes escape XCI to some exte...

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Detalles Bibliográficos
Autores principales: Slavney, Andrea, Arbiza, Leonardo, Clark, Andrew G., Keinan, Alon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751236/
https://www.ncbi.nlm.nih.gov/pubmed/26494842
http://dx.doi.org/10.1093/molbev/msv225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751236/
https://www.ncbi.nlm.nih.gov/pubmed/26494842
http://dx.doi.org/10.1093/molbev/msv225

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